An Overview of Chelation:
Anionic Surfactant Therapy
Chelation therapy is best known for its use in cases of lead toxicity. It is considered the treatment of choice when high levels of lead are detected within the body. It also has an affinity for other toxic metals such as nickel, cadmium, uranium and others. Developed by the military back in the 1940s, this amino-acid combination has been used by both conventional and natural physicians for over 60 years to address toxic metals and flow-related disturbances. Recently the NIH TACT trial (Trial to Assess Chelation Therapy) provided some validation to what practicing clinicians have experienced for years… that people with diabetes and previous anterior myocardial infarctions showed a statistically significant benefit from doing Chelation Therapy over placebo.
Cornerstone Progressive Health uses Doctors Data Labs for reliable testing. Some of the tests we may utilize are…
(click on items in the list below to read more details)
Comprehensive Stool Analysis
- Clostridium Culture
- Result specific commentary provided
- Expanded susceptibilities testing
- Superb turnaround time
- Value priced
Gastrointestinal (GI) complaints are among the most common reasons that patients seek medical care. Symptoms associated with GI disorders include persistent diarrhea, constipation, bloating, indigestion, irritable bowel syndrome and malabsorption. The Comprehensive Stool may be used to assess digestive and absorptive functions, the presence of opportunistic pathogens and to monitor the efficacy of therapeutic remediation of GI disorders.
The Comprehensive Stool Analysis (CSA) is an invaluable non-invasive diagnostic assessment that permits practitioners to objectively evaluate the status of beneficial and imbalanced commensal bacteria including Clostridium species, pathogenic bacteria, yeast/fungus. Precise identification of pathogenic species and susceptibility testing greatly facilitates selection of the most appropriate pharmaceutical or natural treatment agent(s).
Important information regarding the efficiency of digestion and absorption can be gleaned from the measurement of the fecal levels of elastase (pancreatic exocrine sufficiency), muscle and vegetable fibers, carbohydrates, and steatocrit (% total fat).
Inflammation can significantly increase intestinal permeability and compromise assimilation of nutrients. The extent of inflammation, whether caused by pathogens or inflammatory bowel disease (IBD), can be assessed and monitored by examination of the levels of biomarkers such as lysozyme, lactoferrin, white blood cells and mucus. These markers can be used to differentiate between inflammation associated with potentially life threatening inflammatory bowel disease (IBD), which requires life long treatment, and less severe inflammation that can be associated with irritable bowel syndrome (IBS) which is most commonly due to the presence of enteroinvasive pathogens. Lactoferrin is only markedly elevated prior to and during the active phases of IBD, but not with IBS. Monitoring fecal lactoferrin levels in patients with IBD can therefore facilitate timely treatment of IBD, and the test can be ordered separately. Since the vast majority of secretory IgA (sIgA) is normally present in the GI tract where it prevents binding of pathogens and antigens to the mucosal membrane, it is essential to know the status of sIgA in the gut. sIgA is the only bona fide marker of humoral immune status in the GI tract.
Cornerstones of good health include proper digestion of food, assimilation of nutrients, exclusion of pathogens and timely elimination of waste. To obtain benefits from food that is consumed, nutrients must be appropriately digested and then efficiently absorbed into portal circulation. Microbes, larger sized particles of fiber, and undigested foodstuffs should remain within the intestinal lumen. Poor digestion and malabsorption of vital nutrients can contribute to degenerative diseases, compromised immune status, and nutritional deficiencies. Impairment of the highly specific nutrient uptake processes, or compromised GI barrier function (as in “leaky gut syndrome”) can result from a number of causes including: low gastric acid production, chronic maldigestion, food allergen impact on bowel absorptive surfaces, bacterial overgrowth or imbalances (dysbiosis); pathogenic bacteria, yeast and related toxic irritants, and the use of NSAID’s and antibiotics. Impairment of intestinal functions can contribute to the development of food allergies, systemic illnesses, autoimmune disease, and toxic overload from substances that are usually kept in the confines of the bowel for elimination. Efficient remediation of GI dysfunctions incorporates a comprehensive guided approach that should include consideration of elimination of pathogens and exposure to irritants, supplementation of hydrochloric acid, pancreatic enzymes and pre- and probiotics, and repair of the mucosal barrier.
The CSA does not include analysis for parasites; for assessment of the presence for parasites, one should request the Comprehensive Stool Analysis with Parasitology (CSAP).
Red Blood Cell Elements
- Measurement of toxic and functional intracellular elements
- Analysis by ICP-MS
- Result specific commentary provided
- Requires unwashed packed red blood cells
Analysis of red blood cells provides the best diagnostic tool for assessing the status of elements that have important functions inside cells or on blood cell membranes. Blood cell element levels are useful for assessing cardiac influences, anti-inflammatory processes, anemia, immunological function, glucose tolerance and other disorders that are associated specifically with zinc deficiency.
Red blood cell (RBC) analysis is an invaluable diagnostic method for assessing insufficiency or excess of elements that have important functions within cells or on blood cell membranes. An important feature is that the cells are not washed, because this would result in partial loss of some important elements that bind to the plasma membrane, for example, calcium.
RBC element levels are very useful for assessing: cardiotonic influences (magnesium, potassium); anti-inflammatory processes (selenium, copper, zinc); anemia (copper, iron); immunological function (zinc, copper, magnesium), and glucose tolerance (chromium, manganese, and possibly vanadium). Disorders specifically associated with zinc deficiency also are addressed by this analysis. These disorders include loss of visual acuity, dysgeusia, dermatitis and poor wound healing, alopecia, amino acid malabsorption, sexual impotence, decreased production of testosterone, depressed immune function, and growth retardation.
Accurate assessment of essential element status is highly recommended for the determination of appropriate supplementation. The absorption, transport and metabolism of essential elements is highly integrated and regulated. Inappropriate supplementation or dietary imbalance of elements can have significant adverse health effects. For example, excess intake of zinc or molybdenum can result in copper deficiency and, although essential, excess retention of manganese can have serious neurotoxic effects. RBC element analysis is also useful for the assessment of ongoing or very recent EXPOSURE to specific toxic elements that accumulate preferentially in erythrocytes. These toxic elements include arsenic, cadmium, lead, methylmercury and thallium. It is important to keep in mind that elevated levels of the toxic elements in these cells reflect only recent or ongoing exposure and do not provide information about the net retention of the metals in the body.
RBC element analysis should be performed prior to and intermittently throughout the course of detoxification/chelation therapy. Monitoring essential element status is necessary to identify needs for and effectiveness of supplementation. Replacement and maintenance of adequate levels of essential nutrients can markedly reduce the apparent adverse “side effects” associated with the use of detoxification agents, per se, and the general effects of mobilization of toxic elements. It is important to note that some diseases are associated with abnormal levels of blood cell elements that could be misleading with respect to nutritional status. For example, blood cell copper can be temporarily elevated during inflammatory response while liver levels are not.
Urine Toxic & Essential Metal Elements
- Assessment of toxic metal retention and essential element status/wasting
- Monitors detoxification therapy
- Analysis by ICP-MS
- Result specific commentary provided
- Variable urine collection periods
Urine toxic and essential elements analysis is an invaluable tool for the assessment of retention of toxic metals in the body and the status of essential nutrient elements.
Toxic metals do not have any useful physiological function, adversely affect virtually every organ system and disrupt the homeostasis of nutrient elements.
Analysis of the levels of toxic metals in urine after the administration of a metal detoxification agent is an objective way to evaluate the accumulation of toxic metals. Acute metal poisoning is rare. More common, however, is a chronic, low-level exposure to toxic metals that can result in significant retention in the body that can be associated with a vast array of adverse health effects and not chronic disease. Once cannot draw valid conclusions about adverse health effects of metals without assessing net retention. For an individual, toxicity occurs when net retention exceeds physiological tolerance. Net retention is determined by the difference between the rates of assimilation and excretion of metals. To evaluate net retention, one compares the levels of metals in urine before and after the administration of a pharmaceutical metal detoxification agent such as EDTA, DMSA or DMPS. Different compounds have different affinities for specific metals, but all function by sequestering “hidden” metals from deep tissue stores and mobilizing the metals to the kidneys for excretion in the urine. Guidelines for collection periods after administration of the most commonly utilized agents are provided in the table below:
|Common Agents||Half Life||
6 – 24 hrs
|DMPS (IV)||~1 hr||
2 – 6 hrs
|DMPS (oral)||~9 hrs||
6 – 9 hrs
6 – 9 hrs
It is important to perform both pre-and post-provocation urinalysis to permit distinction between ongoing exposures to metals (pre-) and net bodily retention. The pre-provocation urine collection can also be utilized to assess the rate of creatinine clearance if a serum specimen is also submitted.
Many clinicians also request the analysis of essential elements in urine specimens to evaluate nutritional status and the efficacy of mineral supplementation during metal detoxification therapy. Metal detoxification agents can significantly increase the excretion of specific nutrient elements such as zinc, copper, manganese, and molybdenum.
Chromium metabolism authorities suggest that 24-hour chromium excretion likely provides the best assessment of chromium status. Early indication of renal dysfunction can be gleaned from urinary wasting of essential elements such as magnesium, calcium, potassium and sodium in an unprovoked specimen.
Variability in urine volume can drastically affect the concentration of elements. To compensate for urine dilution variation, elements are expressed per unit creatinine for timed collections. For 24-hour collections, elements are reported as both units per 24 hours and units per creatinine.